Understanding the ovarian clock: essential knowledge for pediatricians, Huang Zhongwei

Women experience a decline in fertility as ovarian follicles decrease with age. The ovarian follicles are at their peak numbers in utero and start to decline in numbers upon birth and a non-linear decline throughout a girl’s growing up, reaching adolescence and adulthood. These follicles play a crucial role in maintaining good health by ensuring optimal functions of the cardiovascular, muscoloskeletal, and neurocognitive systems. Despite the vital role of ovaries in women's overall health, the biological processes of ovarian aging remains understudied. Further research is therefore encouraged to better achieve optimal reproductive health.