Non-IgE-mediated Gastrointestinal Food Allergies – What is it and how Should we Manage it?

Non-IgE-mediated gastrointestinal food allergic disorders (non-IgE-GI-FA) account for an unknown proportion of food allergies and include food protein-induced enterocolitis syndrome (FPIES), allergic proctocolitis (FPIAP), and enteropathy (FPE). (1) Non-IgE-GI-FA disorders are separate clinical entities but have many overlapping clinical and histologic features among themselves and with eosinophilic gastroenteropathies. Over the past decade FPIES has emerged as the most actively studied non-IgE-GI-FA, potentially due to acute and distinct clinical features. (2) This presentation focuses on mechanismo of FPIAP and FPIES and need to define the natural history and the pathophysiology of non-IgE-GI-FA to develop non-invasive biomarkers and novel therapies to accelerate resolution.