On Multi-Domain Approaches for Prevention Trials

Observational studies have identified multiple modifiable risk factors associated with increased risk of late-life cognitive impairment and Alzheimer’s disease (AD). However, previous smaller and shorter term prevention trials with single-factor interventions have had disappointing or at best modest results. This presentation will show recent results from the Nordic multi-domain RCT meant to delay cognitive impairment and present ongoing multinational initiatives aiming to dementia/AD prevention.