Integrating the next-generation evidence-based medicine into clinical studies on gut microbiota modulation, Hania Szajewska

The human gut microbiota has been recognized to play an important role in human health. This community of microorganisms residing in the gastrointestinal tract has received considerable attention from the media and science community. There is a notable range of studies emerging over the past years on advancing health through gut microbiota modulation, including use of biotics and fecal microbiota transplants. Evidence-based medicine (EBM) is an approach to medical practice that integrates the best available evidence with clinical expertise and patient values to make informed decisions about patient care. Along with this came the rise of randomized controlled trials (RCTs) to help contribute to systematic reviews and clinical guidelines.  Despite the surge of randomized controlled trials delving into microbiome modifications, the expected benefits of such interventions are not always clear or consistent. Future investigations are therefore encouraged to help policy-makers and healthcare professionals make informed decisions based on the latest evidence.