Do HMOs have a potential role in allergy?

HMOs support the development of the immune system directly by modulating human epithelial cell responses and indirectly by stimulating the growth of healthy gut microbiota. Breast milk that is rich in HMOs, plays an important role in reducing the risk of common allergic diseases in early life.

• Higher levels of 2′FL in breast milk are associated with a lower incidence of IgE-associated eczema among C-section-born infants, with a family risk for allergies4
• Overall HMO profiles influence food sensitisation in infants in the first year of life5
• Addition of 2′FL to infant formulae influences immune responses similar to that of breastfed infants6
• A whey-based, extensively hydrolysed formula containing the 2’FL and LNnT is recommended for the management of CMPA in infants and young children7